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US Patent 9023996 Anti-FLT3 antibodies

Patent 9023996 was granted and assigned to SYNIMMUNE GmbH on May, 2015 by the United States Patent and Trademark Office.

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Grundram Jung0

Hans-Joerg Buehring0

Ludger Grosse-Hovest0

Martin Hofmann0

Steffen Aulwurm0

Date of Patent

May 5, 2015

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Patent Application Number

135187790

Date Filed

December 23, 2010

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Patent Citations Received

US Patent 12005081 Chimeric receptors and methods of use thereof

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US Patent 12012455 Human monoclonal antibodies specific for FLT3 and uses thereof

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US Patent 11945866 Method of eliminating hematopoietic stem cells/hematopoietic progenitors (HSC/HP) in a patient using bi-specific antibodies

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Patent Primary Examiner

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Patent abstract

The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.

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