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US Patent 9023994 Immunoglobulin reduced in thrombogenic agents and preparation thereof

Patent 9023994 was granted and assigned to Omrix Biopharmaceuticals on May, 2015 by the United States Patent and Trademark Office.

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Patent

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Current Assignee

Omrix Biopharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

90239940

Patent Inventor Names

Roni Mintz0

Liliana Bar0

Oleg Belyaev0

Roberto Meidler0

Israel Nur0

Date of Patent

May 5, 2015

Patent Application Number

134707880

Date Filed

May 14, 2012

Patent Primary Examiner

‌

Phuong Huynh

Patent abstract

The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2.

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