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US Patent 9023594 Continuous directed evolution of proteins and nucleic acids

Patent 9023594 was granted and assigned to President and Fellows of Harvard College on May, 2015 by the United States Patent and Trademark Office.

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US Patent 12084663 Incorporation of unnatural amino acids into proteins using base editing

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US Patent 12060553 Evolution of BoNT peptidases

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US Patent 12006520 Evaluation and improvement of nuclease cleavage specificity

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US Patent 11999947 Adenosine nucleobase editors and uses thereof

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US Patent 11932884 High efficiency base editors comprising Gam

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US Patent 11920181 Nuclease profiling system

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US Patent 11912985 Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence

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US Patent 11913040 Evolution of TALENs

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US Patent 11913044 Evolution of cytidine deaminases

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US Patent 11905623 Evolution of site-specific recombinases

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Patent abstract

The present invention discloses generalizable methods of evolving nucleic acids and proteins utilizing continuous directed evolution. The invention discloses methods of passing a nucleic acid from cell to cell in a desired function-dependent manner. The linkage of the desired function and passage of the nucleic acid from cell to cell allows for continuous selection and mutation of the nucleic acid.

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Patent Inventor Names

David R. Liu0

Kevin M. Esvelt0

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US Patent 11760986 Evolution of proteases

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US Patent 11702651 Adenosine nucleobase editors and uses thereof

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US Patent 09023594 Continuous directed evolution of proteins and nucleic acids US Patent 9023594 Continuous directed evolution of proteins and nucleic acids

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Patent Number

090235940

Patent Number

90235940

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=090235940

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Is a

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Current Assignee

President and Fellows of Harvard College

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

090235940

Date of Patent

May 5, 2015

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Patent Application Number

130620980

Date Filed

September 8, 2009

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Official Website

https://pdfpiw.uspto.gov/.piw?Docid=090235940

Patent Primary Examiner

Nicole Kinsey White

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Website URL

https://pdfpiw.uspto.gov/.piw?Docid=09023594

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US Patent 09023594 Continuous directed evolution of proteins and nucleic acids

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Is a

Current assignee

President and Fellows of Harvard College

Patent jurisdiction

United States Patent and Trademark Office

Patent number

09023594

Date of patent

May 5, 2015

Patent application number

13062098

Date Filed

September 8, 2009

Patent primary examiner

Nicole Kinsey White

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