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US Patent 8993731 PD-1 antibody

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Patent abstractTimelineTable: Further ResourcesReferences
Is a
Patent
Patent

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8993731
Patent Inventor Names
Kerry Louise Tyson8
Date of Patent
March 31, 2015
Patent Application Number
13583999
Date Filed
March 9, 2011
Patent Citations Received
‌
US Patent 12077554 CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
1
‌
US Patent 11965008 IL-2 muteins and uses thereof
2
‌
US Patent 11981715 Tissue targeted immunotolerance with a CD39 effector
3
‌
US Patent 11993653 Antibodies and methods of use thereof
4
‌
US Patent 11993651 Anti-lag-3 antibodies and methods of use thereof
5
‌
US Patent 11712433 Compositions comprising PKM2 modulators and methods of treatment using the same
6
‌
US Patent 11746103 ALK-5 inhibitors and uses thereof
‌
US Patent 11779632 IL-2 muteins and uses thereof
...
Patent Primary Examiner
‌
Ilia Ouspenski
Patent abstract

A humanized agonistic antibody which binds human PD-1 comprising a heavy chain wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:1 for CDR-H1, the sequence given in SEQ ID NO: 2 for CDR-H2 and the sequence given in SEQ ID NO: 3 for CDR-H3 and the heavy chain framework region is derived from human sub-group sequence VH4 3-1 4-30.4+JH4 (SEQ ID NO: 33). The disclosure also extends to therapeutic uses of the antibody molecules, compositions and methods for producing said antibody molecules.

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