The present disclosure provides cassettes and methods of using same for the delivery of fluids to a patient using fluid delivery systems. In a general embodiment, the cassettes of the present disclosure include a flexible tube, a housing having a recessed area and first and second ends for holding the flexible tube, and at least two additional components including, for example, different sensors, false reading components for sensors, anti-flow valve means, insertion guides, directional indicators, latch mechanisms, kink-prevention notches, etc. Such additional components provide the cassettes of the present disclosure with several advantages including, for example, quality control, efficiency of use, cost effectiveness, and safety of use.