A cover for a stethoscope having a head and a diaphragm is provided. The cover includes a first region having first and second sides, and a second region configured to be continuous with the first region and including a crimpable material to form-fit around at least the head of the stethoscope so as to cover the head of the stethoscope from contamination. The first side includes adherent material for removably adhering the first region to the diaphragm of the stethoscope and the second side includes an antimicrobial layer including an antimicrobial substance that can neutralize or destroy microbes disposed thereon.