Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yu Gui Gu0
Robert Busch0
Roland E. Dolle0
Yong He0
Chester A. Metcalf, III0
Dylan C. Alexander0
Jason B. Cross0
Ning Yin0
Date of Patent
March 3, 2015
0Patent Application Number
138535620
Date Filed
March 29, 2013
0Patent Primary Examiner
Patent abstract
Aryl substituted diazabicyclooctanes (DBO) compounds that inhibit β-lactamases of class A, class C or class D and potentiate β-lactam antibiotics are disclosed. In particular, this disclosure provides DBO compounds that, when used in the disclosed Synergy MIC Assay with a β-lactam antibiotic at a fixed concentration have an MIC of 8 μg/mL or less against one or more isogenic β-lactamase expressing bacterial strains.
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