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US Patent 8940927 Activators of glucokinase

Patent 8940927 was granted and assigned to METABASIS THERAPEUTICS, INC. on January, 2015 by the United States Patent and Trademark Office.

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Current Assignee
‌
METABASIS THERAPEUTICS, INC.
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8940927
Patent Inventor Names
G. Sridhar Prasad0
Nicholas Brian Raffaele0
Mark D. Erion0
Wenyu Li0
Qun Dang0
Brett C. Bookser0
Feng Tian0
Date of Patent
January 27, 2015
Patent Application Number
13115647
Date Filed
May 25, 2011
Patent Primary Examiner
‌
Venkataraman Balasubramanian
Patent abstract

The present invention provides for novel compounds of Formulas I and II and pharmaceutically acceptable salts and co-crystals thereof which have glucokinase activator activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucokinase activator is indicated, including Type 1 and 2 diabetes, impaired glucose tolerance, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formulas I and II, including salts and co-crystals thereof, and pharmaceutical compositions comprising the same.

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