US Patent 8927500 Peptidomimetic macrocycles
Patent 8927500 was granted and assigned to Aileron Therapeutics on January, 2015 by the United States Patent and Trademark Office.
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Provided herein are peptidomimetic macrocycles containing amino acid sequences with at least two modified amino acids that form an intramolecular cross-link that can help to stabilize a secondary structure of the amino acid sequence. Suitable sequences for stabilization include those with homology to the p53 protein. These sequences can bind to the MDM2 and/or MDMX proteins. Also provided herein are methods of using such macrocycles for the treatment of diseases and disorders, such as cancers or other disorders characterized by a low level or low activity of a p53 protein or high level of activity of a MDM2 and/or MDMX protein.
US Patent 08927500 Peptidomimetic macrocycles US Patent 8927500 Peptidomimetic macrocycles
US Patent 08927500 Peptidomimetic macrocycles
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