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US Patent 8697746 Solid dispersion of alpha-ketoamide derivatives

Patent 8697746 was granted and assigned to Senju Pharmaceutical on April, 2014 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Current Assignee
Senju Pharmaceutical
Senju Pharmaceutical
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
86977460
Patent Inventor Names
Masazumi Yamaguchi0
Andrew Xian Chen0
John Fan0
Date of Patent
April 15, 2014
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Patent Application Number
131822180
Date Filed
July 13, 2011
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Patent Primary Examiner
‌
Brandon Fetterolf
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Patent abstract

A solid dispersion comprising ((1S)-1-((((1S)-1-benzyl-2,3-dioxo-3-(cyclopropylamino)propyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester made amorphous in the presence of a water-soluble cellulosic polymer has improved storage stability. The solid dispersion also has improved solubility for an improved bioavailability.

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