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US Patent 8648041 Double-acylated GLP-1 derivatives

Patent 8648041 was granted and assigned to Novo Nordisk on February, 2014 by the United States Patent and Trademark Office.

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Current Assignee
Novo Nordisk
Novo Nordisk
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8648041
Date of Patent
February 11, 2014
Patent Application Number
12970196
Date Filed
December 16, 2010
Patent Citations Received
‌
US Patent 11833248 Solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid
0
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US Patent 11759503 Compositions of GLP-1 peptides and preparation thereof
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US Patent 11759502 Compositions of GLP-1 peptides and preparation thereof
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US Patent 11759501 Compositions of GLP-1 peptides and preparation thereof
Patent Primary Examiner
‌
Jeffrey E. Russel
Patent abstract

The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at a position corresponding to position 26 of GLP-1(7-37), and a maximum of ten amino acid modifications as compared to GLP-1(7-37), wherein the first K residue is designated K37, and the second K residue is designated K26, which derivative comprises two albumin binding moieties attached to K26 and K37, respectively, wherein the albumin binding moiety comprises a protracting moiety selected from:

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