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US Patent 8470315 Non-natural ribonuclease conjugates as cytotoxic agents

Patent 8470315 was granted and assigned to Quintessence Biosciences on June, 2013 by the United States Patent and Trademark Office.

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Current Assignee
Quintessence Biosciences
Quintessence Biosciences
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8470315
Date of Patent
June 25, 2013
Patent Application Number
11105041
Date Filed
April 13, 2005
Patent Primary Examiner
‌
Robert Mondesi
Patent abstract

The present invention is directed toward the delivery of a toxic protein to pathogenic cells, particularly cancer cells. In preferred embodiments, the toxic protein is a ribonuclease that has been modified to make it toxic to target cells and that can be conjugated to a target cell-specific delivery vector, such as an antibody, for delivery to pathogenic cells.

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