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US Patent 8465734 Methods for increasing protein polyethylene glycol (PEG) conjugation

Patent 8465734 was granted and assigned to AntiCancer on June, 2013 by the United States Patent and Trademark Office.

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Patent abstract

The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, without denaturing the protein. The invention also relates to highly conjugated proteins with decreased immunogenicity and increased circulating half-life.

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