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US Patent 8462981 Spectral unmixing for visualization of samples

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Patent abstractTimelineTable: Further ResourcesReferences
Is a
Patent
Patent

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8462981
Date of Patent
June 11, 2013
Patent Application Number
12755831
Date Filed
April 7, 2010
Patent Citations Received
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US Patent 12116626 AP50 polymerases and uses thereof
3
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US Patent 12060603 Methods for internally controlled in situ assays using padlock probes
4
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US Patent 12071667 Sequence analysis using meta-stable nucleic acid molecules
5
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US Patent 12110548 Bi-directional in situ analysis
6
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US Patent 11713485 Hybridization chain reaction methods for in situ molecular detection
7
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US Patent 11753674 Methods and systems for determining spatial patterns of biological targets in a sample
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US Patent 11761030 Spatially encoded biological assays
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US Patent 11767550 Spatially encoded biological assays
...
Patent Primary Examiner
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Barry Drennan
Patent abstract

Disclosed methods include: acquiring a first sequence of multiple images of a sample, with each image in the first sequence corresponding to a different spectral weighting function; unmixing the first sequence of images into data corresponding to a first set of unmixed images, where each unmixed image in the first set corresponds to a spatial distribution in the sample of a different one of multiple components at a first time; acquiring one or more additional images of the sample and combining the additional images with one or more of the images in the first sequence to form a second sequence of images; unmixing the second sequence of images into data corresponding to a second set of unmixed images; and displaying information about the sample as a function of time based on the data corresponding to the first and second sets of unmixed images.

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