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US Patent 8460705 Threo-DOPS controlled release formulation

Patent 8460705 was granted and assigned to Chelsea Therapeutics International on June, 2013 by the United States Patent and Trademark Office.

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Current Assignee
Chelsea Therapeutics International
Chelsea Therapeutics International
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8460705
Date of Patent
June 11, 2013
Patent Application Number
13418410
Date Filed
March 13, 2012
Patent Primary Examiner
‌
Blessing Fubara
Patent abstract

The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

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