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US Patent 8415155 Cardiomyocyte production

Patent 8415155 was granted and assigned to Cellular Dynamics International on April, 2013 by the United States Patent and Trademark Office.

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Current Assignee
Cellular Dynamics International
Cellular Dynamics International
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
84151550
Patent Inventor Names
Wen Bo Wang0
Nathaniel Beardsley0
Peter Fuhrken0
Steven Kattman0
Casey Stankewicz0
Matt Riley0
Date of Patent
April 9, 2013
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Patent Application Number
129077140
Date Filed
October 19, 2010
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Patent Primary Examiner
‌
Shin-Lin Chen
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Patent abstract

Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of ROCK inhibitors are described. In further aspects, methods for differentiation of stem cells into cardiomyocytes that overcome variability between different stem cell clones and different batch of culture medium are provided.

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