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US Patent 8404846 Inhibitors of protein tyrosine kinase activity

Patent 8404846 was granted and assigned to MethylGene on March, 2013 by the United States Patent and Trademark Office.

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Current Assignee
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MethylGene
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
84048460
Patent Inventor Names
Stéphane Raeppel0
Michael Mannion0
Oscar Mario Saavedra0
Stephen William Claridge0
Arkadii Vaisburg0
Frédéric Gaudette0
Lijie Zhan0
Ljubomir Isakovic0
Date of Patent
March 26, 2013
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Patent Application Number
122009390
Date Filed
August 29, 2008
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Patent Primary Examiner
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Nizal Chandrakumar
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Patent abstract

This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

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