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US Patent 8401799 Antibody design using anti-lipid antibody crystal structures

Patent 8401799 was granted and assigned to Lpath on March, 2013 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Current Assignee
‌
Lpath
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
84017990
Patent Inventor Names
Roger A. Sabbadini0
Tom Huxford0
Jonathan Michael Wojciak0
Date of Patent
March 19, 2013
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Patent Application Number
127946680
Date Filed
June 4, 2010
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Patent Primary Examiner
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Michael Borin
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Patent abstract

Methods for designing optimized antibodies, including optimized humainized or human antibodies, to target bioactive lipids are provided. These methods may be performed in silico and may be intended to enhance binding affinity of an antibody to its original target lipid, and/or to alter binding specificity. Antibodies produced by these methods are also provided, as are methods for using them.

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