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Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Charles Allerson0
Balkrishen Bhat0
Eric E. Swayze0
Prasad Dande0
Richard H. Griffey0
Thazha P. Prakash0
Date of Patent
March 12, 2013
0Patent Application Number
115699390
Date Filed
March 3, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides oligomeric compounds having sufficient complementarity to hybridize to a nucleic acid target and methods for their use in modulating gene expression. In one embodiment the oligomeric compounds comprise double stranded constructs wherein one of the strands capable of hybridizing to a nucleic acid target, and has a plurality of modified ribofuranosyl nucleosides at defined locations. The presence of modifications at such defined positions greatly enhances the properties of the corresponding compositions.
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