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US Patent 8236991 Process for the preparation of substantially pure (2S,3S,5S)-5-amino-2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane

Patent 8236991 was granted and assigned to Aurobindo Pharma on August, 2012 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Aurobindo Pharma

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

82369910

Patent Inventor Names

Ramesh Dandala0

V Raghava Reddy Ambati0

Srinivas Garaga0

Sivakumaran Meenakshisunderam0

Date of Patent

August 7, 2012

Patent Application Number

124518720

Date Filed

June 5, 2008

Patent Primary Examiner

‌

Jafar Parsa

Patent abstract

The present invention relates to the purification of (2S,3S,5S)-5-amino-2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane (III) by making its crystalline acid addition salt, which can be used as such to produce Lopinavir/Ritonavir with high purity and yield. Formula III

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