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US Patent 8222277 Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use

Patent 8222277 was granted and assigned to NicOx on July, 2012 by the United States Patent and Trademark Office.

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Patent
Patent

Patent attributes

Current Assignee
‌
NicOx
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8222277
Patent Inventor Names
Xinqin Fang0
Shiow-Jyi Wey0
Stewart K. Richardson0
Subhash P. Khanapure0
Cheri A. Stevenson0
Chia-En Lin0
David S. Garvey0
Joseph D. Schroeder0
...
Date of Patent
July 17, 2012
Patent Application Number
12980077
Date Filed
December 28, 2010
Patent Primary Examiner
‌
James O. Wilson
Patent abstract

The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders comprising administration of novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent.

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