Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Date of Patent
July 10, 2012
Patent Application Number
11859200
Date Filed
September 21, 2007
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to a process for producing a correctly folded and assembled full-length antibody using an E. coli strain, which comprises fermenting an E. coli strain which leaks periplasmic proteins into the medium, comprising a gene coding for the heavy chain of an antibody functionally linked to a signal sequence coding for a signal peptide, and a second gene coding for the light chain of an antibody, functionally linked to a signal sequence coding for a signal peptide, in a culture medium, where the E. coli strain secretes a full-length antibody into the culture medium, and the full-length antibody is removed from the culture medium.
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