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US Patent 8206977 Tricistronic vectors and uses therefor

Patent 8206977 was granted and assigned to MorphoSys on June, 2012 by the United States Patent and Trademark Office.

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Patent
Patent

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Current Assignee
MorphoSys
MorphoSys
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
8206977
Patent Inventor Names
Yvonne Stark0
Josef Prassler0
Date of Patent
June 26, 2012
Patent Application Number
10522535
Date Filed
July 30, 2003
Patent Primary Examiner
‌
Nancy Vogel
Patent abstract

A tricistronic vector (i.e., a vector capable of expressing three exogenous genes, which are not fused together, under the control of one promoter) effectively can encode an immunoglobulin-presenting polypeptide and two immunoglobulin (Ig) polypeptides. The encoded Ig-presenting polypeptide is able to associate with at least one of the Ig polypeptides via co-expressed associating agents. A vector according to the present invention particularly is suited for phage display technology, e.g., when the Ig-presenting polypeptide is a phage coat protein and the Ig polypeptides associate to form a Fab.

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