An instrument access device comprises at least a first instrument seal 71 to effect a seal around a first instrument extended through the device and a second instrument seal 72 to effect a seal around a second instrument extended through the device. The instrument seals 71, 72 are configured to be arranged in a sealing relationship to a body of a patient. The device also comprises a distal anchoring ring 401 for location within a wound interior and a retractor member 402 extending proximally from the distal anchoring ring 401 to retract laterally the sides of a wound opening.