A mattress buckle for securing the position of a mattress (22) on the base (16) of an adjustable bed (10). The mattress comprises one of a pair of male and female elements of the buckle (12) secured to an upper surface of the bed base (16) and the other of the pair of male and female elements of the buckle (12) secured to the underside of the mattress (22). When these elements of the buckle are interlocked in snap-fit engagement, the mattress is constrained against movement on the base as the adjustable panels of the bed base are articulated relative to one another through various positions of adjustment.