Patent 8158579 was granted and assigned to BIOREXIS PHARMACEUTICAL CORPORATION on April, 2012 by the United States Patent and Trademark Office.
The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and pharmaceutical compositions. The invention also provides the use of the exendin-4/Tf fusion proteins for treatment of Type II diabetes, obesity, and to reduce body weight.