US Patent 8138344 Process for the preparation of rapamycin derivatives

Patent 8138344 was granted and assigned to Novartis on March, 2012 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Novartis

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

8138344

Date of Patent

March 20, 2012

Patent Application Number

12160110

Date Filed

January 22, 2007

Patent Citations Received

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US Patent 11780850 Purification of rapamycin derivatives using temperature induced phase separation

Patent Primary Examiner

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Jason M Nolan

Patent abstract

Processes for the production of a 32-deoxorapamycin from a 32-iodo- or 32-hydroxyrapamycin, wherein the hydroxy group is substituted by the residue of an arylthionocarbonate or an arylthiocarbamate, in the presence of tris(trimethylsilyl)-silan and α,α′-azo-isobutyronitril in organic solvent; and 32-deoxorapamycin in the form of a crystalline solvate.