Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jon A. Wolff0
So Wong0
James E. Hagstrom0
Jason Klein0
Sean D. Monahan0
Darren H. Wakefield0
David B. Rozema0
David L. Lewis0
Date of Patent
March 20, 2012
0Patent Application Number
118404680
Date Filed
August 17, 2007
0Patent Citations Received
0
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Patent Primary Examiner
Patent abstract
The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
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