Patent 8101743 was granted and assigned to Ionis Pharmaceuticals on January, 2012 by the United States Patent and Trademark Office.
Compounds, compositions and methods are provided for modulating the expression of transthyretin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding transthyretin. Methods of using these compounds for modulation of transthyretin expression and for diagnosis and treatment of diseases and conditions associated with expression of transthyretin are provided.