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US Patent 8067431 Chemically modified small molecules

Patent 8067431 was granted and assigned to Nektar Therapeutics on November, 2011 by the United States Patent and Trademark Office.

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Patent abstractTimelineTable: Further ResourcesReferences
Is a
Patent
Patent
1

Patent attributes

Current Assignee
Nektar Therapeutics
Nektar Therapeutics
1
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
80674311
Patent Inventor Names
Tacey Viegas1
Yuan Song1
C. Simone Fishburn1
Chester Leach1
David Lechuga-Ballesteros1
Hema Gursahani1
Mei-Chang Kuo1
Date of Patent
November 29, 2011
1
Patent Application Number
127101671
Date Filed
February 22, 2010
1
Patent Citations Received
‌
US Patent 12016952 Methods of preparing a monodisperse oligo(ethylene glycol) reagent composition
2
Patent Primary Examiner
‌
Sharmila G. Landau
1
Patent abstract

Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.

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