US Patent 8012945 Phage antibodies to radiation-inducible neoantigens

Patent 8012945 was granted and assigned to Vanderbilt University on September, 2011 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

Vanderbilt University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

80129450

Patent Inventor Names

Dennis E. Hallahan0

Raymond Mernaugh0

Date of Patent

September 6, 2011

Patent Application Number

119537800

Date Filed

December 10, 2007

Patent Primary Examiner

‌

Jim Ketter

Patent abstract

A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.