Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Steven Mark Dunn0
Yi Li0
Bent Karsten Jakobsen0
Jonathan Michael Boulter0
Peter Eamon Molloy0
Date of Patent
August 30, 2011
Patent Application Number
12854691
Date Filed
August 11, 2010
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC (SEQ ID NO:126)-HLA-A*0201, the SLLMWITQC (SEQ ID NO:126) peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumor cells. The TCRs have a KD for the said that peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.
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