US Patent 8007996 Methods to identify protein arginine deiminase 4 inhibitors

Patent 8007996 was granted and assigned to University of South Carolina on August, 2011 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

University of South Carolina

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

8007996

Patent Inventor Names

Paul R. Thompson0

Bryan Knuckley0

Date of Patent

August 30, 2011

Patent Application Number

12262436

Date Filed

October 31, 2008

Patent Primary Examiner

‌

Sue Liu

Patent abstract

In accordance with one embodiment of the present disclosure, a method to identify a protein arginine deiminase 4 inhibitor is disclosed. The method includes performing a competitive assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to protein arginine deiminase 4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay.