Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Samuel A. Wickline0
Garry E. Kiefer0
Gregory M. Lanza0
Phillip S. Athey0
Date of Patent
August 23, 2011
0Patent Application Number
116936470
Date Filed
March 29, 2007
0Patent Primary Examiner
Patent abstract
MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of target tissues or organs. In addition, the image contrast may be switched on or off with a presaturation radio frequency pulse, avoiding the necessity obtaining pre-injection and post-injection images.
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