Patent 7989594 was granted and assigned to Celltech R&D Limited on August, 2011 by the United States Patent and Trademark Office.
The present invention provides antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1. Also provided are antibody Fab fragments in which the heavy chain constant region terminates at the interchain cysteine of CH1 to which one or more effector molecules are attached.