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US Patent 7989498 Inhibitors of IMPDH enzyme

Patent 7989498 was granted and assigned to Vertex Pharmaceuticals on August, 2011 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

Vertex Pharmaceuticals

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

David Pearlman0

Catharine Frank0

Daniel Elbaum0

Randy S Bethiel0

Steven M Ronkin0

William Walters0

Dean P Stamos0

Douglas Naegele0

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Date of Patent

August 2, 2011

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Patent Application Number

106719670

Date Filed

September 25, 2003

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Patent Citations Received

US Patent 12012383 Compositions and methods for inhibiting dihydroorotate dehydrogenase

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US Patent 12076315 Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof

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US Patent 11744812 Methods of treatment

Patent Primary Examiner

Shailendra Kumar

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Patent abstract

The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

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