US Patent 7973061 Anaplastic lymphoma kinase modulators and methods of use

Patent 7973061 was granted and assigned to Exelixis on July, 2011 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

Exelixis

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7973061

Date of Patent

July 5, 2011

Patent Application Number

10598911

Date Filed

March 31, 2005

Patent Primary Examiner

‌

Susannah Chung

Patent abstract

The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R1, R2, R3 and R4 are defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions; (Formula I).