A cotton cultivar, designated DP 110 RF, is disclosed. The invention relates to the seeds of cotton cultivar DP 110 RF, to the plants of cotton DP 110 RF and to methods for producing a cotton plant produced by crossing the cultivar DP 110 RF with itself or another cotton variety. The invention further relates to hybrid cotton seeds and plants produced by crossing the cultivar DP 110 RF with another cotton cultivar.