US Patent 7951930 Cultured

Patent 7951930 was granted and assigned to Eisai on May, 2011 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Eisai

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7951930

Date of Patent

May 31, 2011

Patent Application Number

12053198

Date Filed

March 21, 2008

Patent Primary Examiner

‌

Shulamith H. Shafer

Patent abstract

Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell lines were proven to maintain the intercellular adhesive structure, representing a phenomenon similar to polyp formation in individual organisms (mice).