Patent 7939264 was granted and assigned to Gen-Probe on May, 2011 by the United States Patent and Trademark Office.
The present invention pertains to a method for determining the sequence of a polynucleotide, the method relying on the detection of a conformational change in an enzyme that interacts with and processes along the polynucleotide. The detection of a conformational change may be carried out by measuring changes in a fluorophore bound to the enzyme.