Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yasutaka Hoshino0
Albert Z. Kapikian0
Robert M. Chanock0
Date of Patent
April 26, 2011
Patent Application Number
09743338
Date Filed
July 27, 1999
Patent Primary Examiner
Patent abstract
The present invention provides vaccine compositions for protection against human rotaviral disease without significant reactogenicity. Human×bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined in a multivalent formulation which provides a high degree of infectivity and immunogenicity without producing a transient febrile condition. Methods for producing an immunogenic response without producing a transient febrile condition are also provided.
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