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Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Simone Renner0
Eckhard Wolf0
Nadja Herbach0
Rüdiger Wanke0
Alexander Pfeifer0
Andreas Hofmann0
Barbara Kessler0
Date of Patent
April 5, 2011
0Patent Application Number
123482940
Date Filed
January 4, 2009
0Patent Primary Examiner
Patent abstract
The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor. The present invention furthermore relates to uses of these transgenic pigs as clinically relevant animal model systems for studying the pathogenesis and novel therapies for diabetes mellitus type 2, particularly for the maintenance and expansion of pancreatic β-cell mass.
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