Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Norihiro Ueda0
Koji Sagane0
Mamiko Tsuchiya0
Naoaki Watanabe0
Fuminori Ohba0
Itaru Tsukada0
Junko Kai0
Kappei Tsukahara0
...
Date of Patent
March 1, 2011
0Patent Application Number
120607930
Date Filed
April 1, 2008
0Patent Primary Examiner
Patent abstract
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
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