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US Patent 7892856 Flow-controlled magnetic particle manipulation

Patent 7892856 was granted and assigned to Battelle Memorial Institute on February, 2011 by the United States Patent and Trademark Office.

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Patent
Patent
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Current Assignee
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1
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
78928561
Patent Inventor Names
Cynthia J. Bruckner-Lea1
David A. Holman1
Jay W. Grate1
Date of Patent
February 22, 2011
1
Patent Application Number
116462161
Date Filed
December 26, 2006
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Patent Citations Received
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US Patent 11891650 Fluid cartridge with valve mechanism
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Patent Primary Examiner
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Jacob Cheu
1
Patent abstract

Inventive methods and apparatus are useful for collecting magnetic materials in one or more magnetic fields and resuspending the particles into a dispersion medium, and optionally repeating collection/resuspension one or more times in the same or a different medium, by controlling the direction and rate of fluid flow through a fluid flow path. The methods provide for contacting derivatized particles with test samples and reagents, removal of excess reagent, washing of magnetic material, and resuspension for analysis, among other uses. The methods are applicable to a wide variety of chemical and biological materials that are susceptible to magnetic labeling, including, for example, cells, viruses, oligonucleotides, proteins, hormones, receptor-ligand complexes, environmental contaminants and the like.

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