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US Patent 7857955 Coated capillary electrophoresis tubes and system

Patent 7857955 was granted and assigned to Beckman Coulter on December, 2010 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Current Assignee
Beckman Coulter
Beckman Coulter
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
78579551
Patent Inventor Names
Chitra K. Ratnayake1
Isabel C. Flores1
Date of Patent
December 28, 2010
1
Patent Application Number
111506501
Date Filed
June 10, 2005
1
Patent Primary Examiner
‌
Kaj K. Olsen
1
Patent abstract

The invention is directed to a capillary tube for electrophoresis that has a positively charged coating on the capillary inner surface that prevents positively charged analytes from adsorbing to the inner capillary surface. The capillary tube has an inner surface that is coated with a first polymer layer having a plurality of polymer groups comprising polyethylene imine, designated herein as (CH2CH2NH)x. The inner surface of the capillary typically has a second polymer layer covalently bonded to the first polymer layer. The invention includes a capillary tube where two or more than two polymer groups are covalently bonded to each other by a cross-linker. Also provided are an electrophoresis system the uses the coated capillary tubes, a method of performing electrophoresis that utilizes the coated capillary tubes, and a process for preparing the coated capillary tubes.

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