Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Philip A. Jennings0
Benjamin P. Woolven0
Ian M. Tomlinson0
Jennifer A. Lee0
Anthony G. Doyle0
Date of Patent
December 7, 2010
0Patent Application Number
116702610
Date Filed
February 1, 2007
0Patent Primary Examiner
Patent abstract
The present invention provides a domain antibody construct which binds to human TNF-α, with the construct comprising:(a) a domain antibody (dAb) which binds to human TNF-α;(b) a modified hinge region sequence;(c) a human or primate heavy chain constant region sequence having a truncated CH1 domain of not more than 20 residues,wherein the modified hinge region sequence contains either a deletion or a single amino acid substitution of at least one cysteine residue which normally facilitates disulfide bond formation between heavy and light antibody chains.
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