US Patent 7838659 Herpesvirus ribozymes and vectors

Patent 7838659 was granted and assigned to University of Florida on November, 2010 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

University of Florida

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7838659

Date of Patent

November 23, 2010

Patent Application Number

12036365

Date Filed

February 25, 2008

Patent Primary Examiner

‌

Brian Whiteman

Patent abstract

Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.