Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yoshinobu Higuchi0
Takenori Ishizawa0
Tatsuya Kato0
Tatsuya Tamura0
Akie Honma0
Akira Okamachi0
Haruhiko Sato0
Hitoshi Ikeya0
...
Date of Patent
October 5, 2010
0Patent Application Number
115471580
Date Filed
April 1, 2005
0Patent Primary Examiner
Patent abstract
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
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