US Patent 7786133 Chemically modified small molecules

Patent 7786133 was granted and assigned to Nektar (pulminary therapeutics business unit) on August, 2010 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Nektar (pulminary therapeutics business unit)

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7786133

Date of Patent

August 31, 2010

Patent Application Number

11015196

Date Filed

December 16, 2004

Patent Citations Received

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US Patent 12016952 Methods of preparing a monodisperse oligo(ethylene glycol) reagent composition

Patent Primary Examiner

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Sharmila Gollamudi Landau

Patent abstract

The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a monodisperse or bimodal water-soluble oligomer composition. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the small molecule drug not attached to the water-soluble oligomer.