Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jack Mathew Webster0
Rong Zhang0
Faisal Ahmed Syud0
Date of Patent
August 10, 2010
0Patent Application Number
123379410
Date Filed
December 18, 2008
0Patent Primary Examiner
Patent abstract
An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an engineered disulfide bridge between two natural or un-natural amino acids in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
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